Amelanotic Uveal Melanomas Evaluated by Indirect Ophthalmoscopy Reveal Better Long-Term Prognosis Than Pigmented Primary Tumours—A Single Centre Experience

Cancers

Martyna Elas¹  Przemysław M. Płonka¹  Piotr Donizy²  Bożena Romanowska-Dixon³  Anna Markiewicz³  Monika Nowak⁴  Mai P. Hoang⁵  Jolanta Orłowska-Heitzmann⁶  Mateusz Krzyziński⁷  Przemysław Biecek⁷ 

[1] Department of Biophysics and Cancer Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, 30-387 Krakow, Poland;Department of Clinical and Experimental Pathology, Division of Clinical Pathology, Wroclaw Medical University, 50-556 Wroclaw, Poland;Department of Ophthalmology and Ocular Oncology, Faculty of Medicine, Jagiellonian University Medical College, 31-501 Krakow, Poland;Department of Ophthalmology and Ocular Oncology, University Hospital, 31-501 Krakow, Poland;Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA;Department of Pathomorphology, University Hospital in Krakow, 30-688 Krakow, Poland;Faculty of Mathematics and Information Science, Warsaw University of Technology, 00-628 Warsaw, Poland;

关键词: pigmentation;    uveal melanoma;    amelanotic;    ocular melanoma;    melanoma;    melanoma pigmentation;   

DOI  :  10.3390/cancers14112753

来源: DOAJ

【 摘 要 】

(1) Background: There is a constant search for new prognostic factors that would allow us to accurately determine the prognosis, select the type of treatment, and monitor the patient diagnosed with uveal melanoma in a minimally invasive and easily accessible way. Therefore, we decided to evaluate the prognostic role of its pigmentation in a clinical assessment. (2) Methods: The pigmentation of 154 uveal melanomas was assessed by indirect ophthalmoscopy. Two groups of tumours were identified: amelanotic and pigmented. The statistical relationships between these two groups and clinical, pathological parameters and the long-term survival rate were analyzed. (3) Results: There were 16.9% amelanotic tumours among all and they occurred in younger patients (p = 0.022). In pigmented melanomas, unfavourable prognostic features such as: epithelioid cells (p = 0.0013), extrascleral extension (p = 0.027), macronucleoli (p = 0.0065), and the absence of BAP1 expression (p = 0.029) were statistically more frequently observed. Kaplan–Meier analysis demonstrated significantly better overall (p = 0.017) and disease-free (p < 0.001) survival rates for patients with amelanotic tumours. However, this relationship was statistically significant for lower stage tumours (AJCC stage II), and was not present in larger and more advanced stages (AJCC stage III). (4) Conclusions: The results obtained suggested that the presence of pigmentation in uveal melanoma by indirect ophthalmoscopy was associated with a worse prognosis, compared to amelanotic lesions. These findings could be useful in the choice of therapeutic and follow-up options in the future.

【 授权许可】

Unknown