OXA-48 Carbapenemase-Producing Enterobacterales in Spanish Hospitals: An Updated Comprehensive Review on a Rising Antimicrobial Resistance

Antibiotics

AntonioJesús Láinez-Ramos-Bossini¹  NicolásFrancisco Fernández-Martínez¹  Eladio Jiménez-Mejías¹  LuisMiguel Martín-delosReyes²  Jairo López-Gómez³  Elena Moreno-Roldán³  Mario Rivera-Izquierdo³  Carlos Rivera-Izquierdo⁴  Virginia Martínez-Ruiz⁵  Pablo Redruello-Guerrero⁶ 

[1] [e-mail] (C.R.-I.);Department of Preventive Medicine and Public Health, Reina Sofía University Hospital, 14004 Córdoba, Spain;Department of Preventive Medicine and Public Health, University of Granada, 18016 Granada, Spain;Department of Radiology, University of Granada, 18016 Granada, Spain;School of Medicine, University of Granada, 18016 Granada, Spain;Service of Internal Medicine, San Cecilio University Hospital, 18016 Granada, Spain;

关键词: OXA-48;    carbapenem;    carbapenemase;    Spain;    outbreak;    multiresistant;   

DOI  :  10.3390/antibiotics10010089

来源: DOAJ

【 摘 要 】

Carbapenemase-producing Enterobacterales (CPE) are significant contributors to the global public health threat of antimicrobial resistance. OXA-48-like enzymes and their variants are unique carbapenemases with low or null hydrolytic activity toward carbapenems but no intrinsic activity against expanded-spectrum cephalosporins. CPEs have been classified by the WHO as high-priority pathogens given their association with morbidity and mortality and the scarce number of effective antibiotic treatments. In Spain, the frequency of OXA-48 CPE outbreaks is higher than in other European countries, representing the major resistance mechanism of CPEs. Horizontal transfer of plasmids and poor effective antibiotic treatment are additional threats to the correct prevention and control of these hospital outbreaks. One of the most important risk factors is antibiotic pressure, specifically carbapenem overuse. We explored the use of these antibiotics in Spain and analyzed the frequency, characteristics and prevention of CPE outbreaks. Future antibiotic stewardship programs along with specific preventive measures in hospitalized patients must be reinforced and updated in Spain.

【 授权许可】

Unknown