Indomethacin therapy in hydramnios.

Journal of Postgraduate Medicine

关键词: Adult;    Anti-Inflammatory Agents;    Non-Steroidal;    administration &;    dosage;    Drug Administration Schedule;    Female;    Follow-Up Studies;    Gestational Age;    Human;    Indomethacin;    administration &;    dosage;    Polyhydramnios;    drug therapy;    ultrasonography;    Pregnancy;    Pregnancy Outcome;    Severity of Illness Index;    Treatment Outcome;    Ultrasonography;    Prenatal;    methods;   

DOI  :  

来源: DOAJ

【 摘 要 】

AIM: The use of indomethacin in treatment of hydramnios was evaluated. SUBJECTS & METHODS: Twelve patients with symptomatic hydramnios were treated with indomethacin (2.2- 3.0 mg/kg body weight/day). RESULTS: The treatment was started at a gestational age of 31.17-/+7.94 weeks and continued for 3.74-/+2.3 weeks. Eleven patients responded to the therapy both subjectively and objectively and pregnancies were prolonged by 4.6-/+3.1 weeks (range 0.1-10 weeks). Five women had term deliveries. Six patients had a favourable perinatal outcome. Four patients who had a known congenital anomaly in the foetus, delivered stillborn babies or had an early neonatal death. One patient who did not follow up after commencing therapy delivered a full-term stillbirth. One patient delivered within 1 day of starting therapy. Indomethacin therapy caused no maternal complications. CONCLUSION: Indomethacin was effective in the management of hydramnios and preventing it′s complications.

【 授权许可】

Unknown