18F-FDG PETCT and 68Ga-DOTA PETCT mismatch with in vivo histopathological characterization of low-grade neuroendocrine pancreatic tumor

European Journal of Hybrid Imaging

Felipe de Galiza Barbosa¹  Thales Parenti Silveira²  Alessandra Corte Real Salgues³  Marcello Moro Queiroz³  Carlos Diego Holanda Lopes³  Emerson Shigueaki Abe³  Marcel Cerqueira Cesar Machado³  Fernanda Cunha Capareli³ 

[1] Department of Diagnostic Imaging and Nuclear Medicine, Hospital Sírio-Libanês (HSL);Department of Pathology, Hospital Sírio-Libanês (HSL);Oncology Center, Hospital Sírio-Libanês (HSL);

关键词: Neuroendocrine;    Low grade;    68Ga-DOTA PETCT;    In vivo;    Mismatch;    Pancreatic tumor;   

DOI  :  10.1186/s41824-021-00103-4

来源: DOAJ

【 摘 要 】

Abstract Background Pancreatic neuroendocrine tumor (PNET) is a subgroup of neuroendocrine tumor (NET) that has unique biology and natural history. The histological classification has a major role in the management of this pathology, but in recent years Gallium 68 dotatate (68Ga-DOTA) scanning is at the center of a discussion about how these imaging technologies can modify clinical management of neuroendocrine tumors and how their results are correlated to Ki67 index. Method We hereby describe a case of a patient that investigated an unspecific stable pancreatic nodule suspected of high-grade NET after evaluation with 68Ga-DOTATOC positron emission tomography—computed tomography (PETCT) and 18F-Fluorodeoxyglucose (18F-FDG) PETCT. Results The images corroborate the hypothesis of high-grade NET based on the standard uptake value (SUV) described in both image exams (16.4 in 18FDG PETCT and 9.2 in 68Ga-DOTATOC PETCT). After surgery, the histopathological analyses revealed a localized grade 2 well-differentiated NET, Ki-67 of 4.7, glucose transport proteins 1 (GLUT1) negative by immunohistochemistry, evidencing a rare case of mismatch between the functional image and the in vivo characterization of the neoplasm. Conclusion Functional imaging of neuroendocrine tumors with different modalities of PETCT is a well-described strategy for evaluating PNET and can dictate conducts in some cases. However, histopathological analysis is crucial to confirm the grade and prognosis related to this disease.

【 授权许可】

Unknown