Metabolic Profiling and Metabolites Fingerprints in Human Hypertension: Discovery and Potential

Metabolites

Hongyu Qiu¹  John Oloche Onuh¹ 

[1] Center for Molecular and Translational Medicine, Institute of Biomedical Sciences, Georgia State University, Atlanta, GA 30303, USA;

关键词: metabolomics;    hypertension;    metabolites fingerprints;    biomarkers;    aging;   

DOI  :  10.3390/metabo11100687

来源: DOAJ

【 摘 要 】

Early detection of pathogenesis through biomarkers holds the key to controlling hypertension and preventing cardiovascular complications. Metabolomics profiling acts as a potent and high throughput tool offering new insights on disease pathogenesis and potential in the early diagnosis of clinical hypertension with a tremendous translational promise. This review summarizes the latest progress of metabolomics and metabolites fingerprints and mainly discusses the current trends in the application in clinical hypertension. We also discussed the associated mechanisms and pathways involved in hypertension’s pathogenesis and explored related research challenges and future perspectives. The information will improve our understanding of the development of hypertension and inspire the clinical application of metabolomics in hypertension and its associated cardiovascular complications.

【 授权许可】

Unknown