Oxidative Stress and NADPH Oxidase: Connecting Electromagnetic Fields, Cation Channels and Biological Effects

International Journal of Molecular Sciences

Christos D. Georgiou¹  Lukas H. Margaritis² 

[1] Department of Biology, Section of Genetics, Cell & Developmental Biology, University of Patras, 10679 Patras, Greece;Section of Cell Biology and Biophysics, Department of Biology, National and Kapodistrian University of Athens, 26504 Athens, Greece;

关键词: EMF;    voltage-gated calcium channels;    cation channels;    ROS;    DNA damage;    carcinogenesis;   

DOI  :  10.3390/ijms221810041

来源: DOAJ

【 摘 要 】

Electromagnetic fields (EMFs) disrupt the electrochemical balance of biological membranes, thereby causing abnormal cation movement and deterioration of the function of membrane voltage-gated ion channels. These can trigger an increase of oxidative stress (OS) and the impairment of all cellular functions, including DNA damage and subsequent carcinogenesis. In this review we focus on the main mechanisms of OS generation by EMF-sensitized NADPH oxidase (NOX), the involved OS biochemistry, and the associated key biological effects.

【 授权许可】

Unknown