Impaired fasting glucose levels in overweight or obese subjects for screening of type 2 diabetes in Korea

The Korean Journal of Internal Medicine

Kun-Ho Yoon¹  Jin-Hee Lee¹  Sun-Young Lim¹  Jeong-Taek Woo²  Suk Chon²  Sang Youl Rhee²  Seon-Ah Cha³  Seung-Hyun Ko³  Kook-Rye Kim³  Jae-Seung Yun³  Yu-Bae Ahn³  Korean Diabetes Prevention Study Investigators⁴ 

[1] Catholic Institute of Smart Healthcare Center, Institute of Biomedical Industry, The Catholic University of Korea, Seoul, Korea;Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, Korea;Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, St. Vincent’s Hospital, The Catholic University of Korea, Suwon, Korea;;

关键词: diabetes mellitus, type 2;    prediabetic state;    impaired fasting glucose;    overweight;    hemoglobin a1c;   

DOI  :  10.3904/kjim.2019.171

来源: DOAJ

【 摘 要 】

Background/Aims We examined the concordance rate among fasting plasma glucose (FPG), 2-hour post-challenge glucose (2hr PG), and hemoglobin A1c (HbA1c) in the diagnosis of diabetes in a population with a high-risk for type 2 diabetes mellitus (T2DM) in Korea. Methods Among the participants from the Korean Diabetes Prevention Study, individuals with FPG ≥ 100 mg/dL, body mass index (BMI) ≥ 23.0 kg/m2, and no previous history of T2DM were consecutively enrolled after a 75 g glucose tolerance test. We analyzed the differences in the clinical characteristics in subjects with stage 1 (FPG, 100 to 109 mg/dL) and stage 2 (FPG, 110 to 125 mg/dL) impaired fasting glucose (IFG). Results Of 1,637 participants, 27.2% had T2DM and 59.3% had IFG and/or impaired glucose tolerance (IGT). The mean age was 55.0 ± 8.1 years and the mean BMI was 26.3 ± 2.7 kg/m2. Based on FPG criteria, 515 (31.4%) and 352 (21.5%) subjects were classified as having stage 1 and stage 2 IFG, respectively. The 19.0% of stage 1 and 43.5% of stage 2 subjects showed 2hr PG levels in the diabetic range. Even for those in the normal FPG range, 63 (9.5%) participants showed a 2hr PG level of ≥ 200 mg/dL. Of 446 subjects with newly-diagnosed diabetes, 340 (76.2%) showed FPG levels < 126 mg/dL. Conclusions The oral glucose tolerance test should be actively considered for Korean adults who are overweight or obese with the IFG range (FPG, 100 to 125 mg/ dL) to allow for early detection of diabetes and prompt intervention.

【 授权许可】

Unknown