The intriguing regulators of muscle mass in sarcopenia and muscular dystrophy

Frontiers in Aging Neuroscience

Akihiko eYamaguchi¹  wataru eAoi²  Kunihiro eSakuma³ 

[1] Health Sciences University of Hokkaido;Kyoto Prefectural University Kyoto,;Toyohashi University of Technology;

关键词: Autophagy;    Muscular Dystrophies;    Myostatin;    Sarcopenia;    mTOR;    serum rsponse factor;   

DOI  :  10.3389/fnagi.2014.00230

来源: DOAJ

【 摘 要 】

Recent advances in our understanding of the biology of muscle have led to new interest in the pharmacological treatment of muscle wasting. Loss of muscle mass and increased intramuscular fibrosis occur in both sarcopenia and muscular dystrophy. Several regulators (mTOR, serum response factor, atrogin-1, myostatin, etc) seem to modulate protein synthesis and degradation or transcription of muscle-specific genes during both sarcopenia and muscular dystrophy. This review provides an overview of the adaptive changes in several regulators of muscle mass in both sarcopenia and muscular dystrophy.

【 授权许可】

Unknown