Heterocyclic systems containing S/N regioselective nucleophilic competition: Facile synthesis, antitubercular and antimicrobial activity of thiohydantoins and iminothiazolidinones containing the benzo

Journal of the Serbian Chemical Society

Patel M.R.¹  Kachhadia V.V.¹  Joshi H.S.¹ 

[1] Saurashtra University - Department of Chemistry, Gujarat, India;

关键词: iminothiazolidinone;    thiohydantoin;    antitubercular activity;    antimicrobialactivity.;   

DOI  :  10.2298/JSC0502153K

来源: DOAJ

【 摘 要 】

The required compounds N-aryl-N'-(3-chloro-2-benzo[b]thenoyl)-thioureas 1a-k were prepared by condensing 3-chloro-2-benzo[b]thenoyl chloride with different arylamines using ammonium thiocyanate, which in turn when treated with chloroacetic acid, yielded 1-aryl-3-(3-chloro-2-benzo[b]thenoyl)thiohydantoins 2a-k, while in the presence of sodium acetate treated with chloroacetic acid, yielded 2-arylimino-3-(3-chloro-2-benzo[b]thenoyl)-4-thiazolidinones 3a-k. All the synthesized compounds were screened for their antitubercular and antimicrobial activities. Some selected compounds were selected for their further antitubercular screening.

【 授权许可】

Unknown