Procalcitonin and BISAP score versus c-reactive protein and APACHE II score in early assessment of severity and outcome of acute pancreatitis

Vojnosanitetski Pregled

关键词: pancreatitis, acute necrotizing;    severity of illness index;    prognosis;    apache;    treatment outcome;   

DOI  :  10.2298/VSP1205425B

来源: DOAJ

【 摘 要 】

Background/Aim. Early assessment of severity and continuous monitoring ofpatients are the key factors for adequate treatment of acute pancreatitis(AP). The aim of this study was to determine the value of procalcitonin(PCT) and Bedside Index for Severity in Acute Pancreatitis (BISAP) scoringsystem as prognostic markers in early stages of AP with comparison to otherestablished indicators such as Creactive protein (CRP) and Acute Physiologyand Chronic Health Evaluation (APACHE) II score. Methods. This prospectivestudy included 51 patients (29 with severe AP). In the first 24 h ofadmission in all patients the APACHE II score and BISAP score, CRP and PCTserum concentrations were determined. The values of PCT serum concentrationsand BISAP score were compared with values of CRP serum concentrations andAPACHE II score, in relation to the severity and outcome of the disease.Results. Values of PCT, CRP, BISAP score and APACHE II score, measured at 24h of admission, were significantly elevated in patients with severe form ofthe disease. In predicting severity of AP at 24 h of admission, sensitivityand specificity of the BISAP score were 74% and 59%, respectively, APACHE IIscore 89% and 69%, respectively, CRP 75% and 86%, respectively, and PCT 86%and 63%, respectively. It was found that PCT is highly significant predictorof the disease outcome (p < 0,001). Conclusion. In early assessment of APseverity, PCT has better predictive value than CRP, and similar to theAPACHE II score. APACHE II score is a stronger predictor of the diseaseseverity than BISAP score. PCT is a good predictor of AP outcome.

【 授权许可】

Unknown