The Role of Non-Coding RNAs in the Regulation of the Proto-Oncogene MYC in Different Types of Cancer

Biomedicines

Anton Markovich Schwartz¹  Ekaterina Mikhailovna Stasevich¹  Lyudmila Sergeevna Zinevich²  Denis Eriksonovich Demin³  Matvey Mikhailovich Murashko³ 

[1] Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia;Koltsov Institute of Developmental Biology, Russian Academy of Sciences, 119334 Moscow, Russia;Laboratories for the Transmission of Intracellular Signals in Normal and Pathological Conditions, Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, Russia;

关键词: MYC;    miRNAs;    lncRNA;    circRNA;    cancer;   

DOI  :  10.3390/biomedicines9080921

来源: DOAJ

【 摘 要 】

Alterations in the expression level of the MYC gene are often found in the cells of various malignant tumors. Overexpressed MYC has been shown to stimulate the main processes of oncogenesis: uncontrolled growth, unlimited cell divisions, avoidance of apoptosis and immune response, changes in cellular metabolism, genomic instability, metastasis, and angiogenesis. Thus, controlling the expression of MYC is considered as an approach for targeted cancer treatment. Since c-Myc is also a crucial regulator of many cellular processes in healthy cells, it is necessary to find ways for selective regulation of MYC expression in tumor cells. Many recent studies have demonstrated that non-coding RNAs play an important role in the regulation of the transcription and translation of this gene and some RNAs directly interact with the c-Myc protein, affecting its stability. In this review, we summarize current data on the regulation of MYC by various non-coding RNAs that can potentially be targeted in specific tumor types.

【 授权许可】

Unknown