Microbial Colonization From the Fetus to Early Childhood—A Comprehensive Review

Frontiers in Cellular and Infection Microbiology

Franziska Righini-Grunder²  Rashikh Choudhury³  Tanja Restin⁴  Raphael N. Vuille-dit-Bille⁴  Viola Senn⁵  Felix Scholkmann⁵  Dirk Bassler⁵ 

[1] Department of Pediatric Surgery, University Children’s Hospital of Basel, Basel, Switzerland;Division of Pediatric Gastroenterology, Hepatology and Nutrition, Children’s Hospital Lucerne, Lucerne, Switzerland;Division of Transplantation Surgery, Department of Surgery, University of Colorado Hospital, Aurora, CO, United States;Institute of Physiology, University of Zurich, Zurich, Switzerland;Newborn Research Zurich, Department of Neonatology, University Hospital Zurich and University of Zurich, Zurich, Switzerland;

关键词: microbiome;    microbiota;    fetus;    newborn;    infant;   

DOI  :  10.3389/fcimb.2020.573735

来源: DOAJ

【 摘 要 】

The development of the neonatal gastrointestinal tract microbiota remains a poorly understood process. The interplay between neonatal (gestational age, genetic background), maternal (mode of delivery, nutritional status) and environmental factors (antibiotic exposure, available nutrition) are thought to influence microbial colonization, however, the exact mechanisms are unclear. Derangements in this process likely contribute to various gastrointestinal diseases including necrotizing enterocolitis and inflammatory bowel disease. As such, enhanced understanding of microbiota development may hold the key to significantly reduce the burden of gastrointestinal disease in the pediatric population. The most debatable topics during microbial seeding and possible future treatment approaches will be highlighted in this review.

【 授权许可】

Unknown