Cognitive Effects of Montelukast: A Pharmaco-EEG Study

Brain Sciences

Christopher Höhn¹  Bernhard Iglseder²  Fabian Schwimmbeck³  Eugen Trinka³  Fabio Rossini³  Wolfgang Staffen³  Nora Renz³  Yvonne Höller⁴  Markus Lobendanz⁵  Peter Reichenpfader⁶  Ludwig Aigner⁷ 

[1] Centre for Cognitive Neuroscience (CCNS), Department of Psychology, University of Salzburg, 5020 Salzburg, Austria;Department of Geriatric Medicine, Christian Doppler University Hospital, Paracelsus Medical University, 5020 Salzburg, Austria;Department of Neurology, Christian Doppler University Hospital, Paracelsus Medical University, 5020 Salzburg, Austria;Faculty of Psychology, University of Akureyri, 600 Akureyri, Iceland;Medical Practice for Pulmonology Lobendanz, 5020 Salzburg, Austria;Medical Practice for Pulmonology Reichenpfader, 5020 Salzburg, Austria;Spinal Cord Injury and Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University, 5020 Salzburg, Austria;

关键词: montelukast;    EEG;    cognitive tests;    anti-inflammatory drug;    leukotriene receptor antagonist;   

DOI  :  10.3390/brainsci11050547

来源: DOAJ

【 摘 要 】

Montelukast is a well-established antiasthmatic drug with little side effects. It is a leukotriene receptor antagonist and recent research suggests cognitive benefits from its anti-inflammatory actions on the central nervous system. However, changes in brain activity were not directly shown so far in humans. This study aims to document changes in brain activity that are associated with cognitive improvement during treatment with Montelukast. We recorded EEG and conducted neuropsychological tests in 12 asthma-patients aged 38–73 years before and after 8 weeks of treatment with Montelukast. We found no significant changes on neuropsychological scales for memory, attention, and mood. In the EEG, we found decreased entropy at follow up during rest (p < 0.005). During episodic memory acquisition we found decreased entropy (p < 0.01) and acceleration of the background rhythm (p < 0.05). During visual attention performance, we detected an increase in gamma power (p < 0.005) and slowing of the background rhythm (p < 0.05). The study is limited by its small sample size, young age and absence of baseline cognitive impairment of the participants. Unspecific changes in brain activity were not accompanied by cognitive improvement. Future studies should examine elderly patients with cognitive impairment in a double-blind study with longer-term treatment by Montelukast.

【 授权许可】

Unknown