The Roles of Immune Cells in the Pathogenesis of Fibrosis

International Journal of Molecular Sciences

Enyu Huang¹  Fan Xiao¹  Liwei Lu¹  Xiaohui Wang¹  Dajun Hu²  Na Peng² 

[1] Department of Pathology and Shenzhen Institute of Research and Innovation, The University of Hong Kong, Hong Kong, China;Department of Rheumatology and Immunology, the Second People’s Hospital of Three Gorges University, Yichang 443000 China;

关键词: fibrosis;    innate immune cells;    adaptive immune cells;    myofibroblast;    molecular mechanism;   

DOI  :  10.3390/ijms21155203

来源: DOAJ

【 摘 要 】

Tissue injury and inflammatory response trigger the development of fibrosis in various diseases. It has been recognized that both innate and adaptive immune cells are important players with multifaceted functions in fibrogenesis. The activated immune cells produce various cytokines, modulate the differentiation and functions of myofibroblasts via diverse molecular mechanisms, and regulate fibrotic development. The immune cells exhibit differential functions during different stages of fibrotic diseases. In this review, we summarized recent advances in understanding the roles of immune cells in regulating fibrotic development and immune-based therapies in different disorders and discuss the underlying molecular mechanisms with a focus on mTOR and JAK-STAT signaling pathways.

【 授权许可】

Unknown