Influence of Belatacept- vs. CNI-Based Immunosuppression on Vascular Stiffness and Body Composition

Journal of Clinical Medicine

Zbigniew Heleniak¹  Georgios Eleftheriadis²  Fabian Halleck²  Klemens Budde²  Sarah Illersperger²  Marcel G. Naik²  Bilgin Osmanodja²  Simon Ronicke² 

[1] Department of Nephrology, Transplantology and Internal Medicine, Medical University of Gdansk, 7 Dębinki Street, 80-952 Gdańsk, Poland;Medizinische Klinik mit Schwerpunkt Nephrologie und Internistische Intensivmedizin, Charité–Universitätsmedizin, 10117 Berlin, Germany;

关键词: kidney transplantation;    belatacept;    arterial stiffness;   

DOI  :  10.3390/jcm11051219

来源: DOAJ

【 摘 要 】

Background: Arterial stiffness and phase angle (PhA) have gained importance as a diagnostic and prognostic parameter in the management of cardiovascular disease. There are few studies regarding the differences in arterial stiffness and body composition between renal transplant recipients (RTRs) receiving belatacept (BELA) vs. calcineurin inhibitors (CNI). Therefore, we investigated the differences in arterial stiffness and body composition between RTRs treated with different immunosuppressants, including BELA. Methods: In total, 325 RTRs were enrolled in the study (mean age 52.2 years, M −62.7%). Arterial stiffness was determined with an automated oscillometric device. All body composition parameters were assessed, based on bioelectrical impedance analysis (BIA), and laboratory parameters were obtained from the medical files of the patients. Results: We did not detect any significant difference in terms of arterial stiffness and PhA in RTRs undergoing different immunosuppressive regimens, based on CsA, Tac, or BELA. Age was an essential risk factor for greater arterial stiffness. The PhA was associated with age, BMI, time of dialysis before transplantation, and kidney graft function. Conclusion: No significant differences in arterial stiffness and PhA were observed in RTRs under different immunosuppressive regimens. While our data provide additional evidence for arterial stiffness and PhA in RTRs, more research is needed to fully explore these cardiovascular risk factors and the impact of different immunosuppressive regimens.

【 授权许可】

Unknown