Concise Reviews: Cancer Stem Cell Targeted Therapies: Toward Clinical Success

Stem Cells Translational Medicine

Yan Yan¹  Amar Desai¹  Stanton L. Gerson¹ 

[1] Department of Medicine Case Western Reserve University Cleveland Ohio USA;

关键词: Cancer stem cells;    Epigenetics;    Immunotherapy;    Metastasis;   

DOI  :  10.1002/sctm.18-0123

来源: DOAJ

【 摘 要 】

Abstract Cancer stem cells (CSCs) are a subpopulation of cells within tumors that possess the stem cell characteristics of self‐renewal, quiescence, differentiation, and the ability to recapitulate the parental tumor when transplanted into a host. CSCs are correlated with poor clinical outcome due to their contribution to chemotherapy resistance and metastasis. Multiple cell surface and enzymatic markers have been characterized to identify CSCs within a heterogeneous tumor, and here we summarize ongoing preclinical and clinical efforts to therapeutically target these cells and improve patient outcomes. Stem Cells Translational Medicine 2019;8:75–81

【 授权许可】

Unknown