The relationship between COVID-19 infection and intracranial hemorrhage: A systematic review

Brain Hemorrhages

Jason H. Huang¹  Dongxia Feng²  Anthony V. Nguyen³  Yilu Zhang³  Samuel R. Daly³ 

[1] Department of Neurosurgery, Baylor Scott and White Health, Scott and White Medical Center, Temple, TX, USA;Corresponding authors at: 2401 S 31st Street, Temple, TX 76508, USA.;Department of Neurosurgery, Baylor Scott and White Health, Scott and White Medical Center, Temple, TX, USA;

关键词: Covid-19;    SARS-CoV-2;    Intracranial Hemorrhage;    Subarachnoid Hemorrhage;    Intraparenchymal Hemorrhage;    Cerebral Venous Thrombosis;   

DOI  :  

来源: DOAJ

【 摘 要 】

Introduction: In addition to the deleterious effects Covid-19 has on the pulmonary and cardiovascular systems, COVID-19 can also result in damage to the nervous system. This review aims to explore current literature on the association between COVID-19 and intracranial hemorrhage (ICH). Methods: We conducted a systematic review of PubMed for literature published on COVID-19 and ICH. Ninety-four of 295 screened papers met inclusion criteria. Results: The literature addressed incidence and mortality of ICH associated with Covid-19. It also revealed cases of COVID-19 patients with subarachnoid hemorrhage, intraparenchymal hemorrhage, subdural hematomas, and hemorrhage secondary to cerebral venous thrombosis and ischemic stroke. ICH during COVID-19 infections was associated with increased morbidity and mortality. Risk factors for ICH appeared to be therapeutic anticoagulation, ECMO, and mechanical ventilation. Outcomes varied widely, depending on the severity of COVID-19 infection and neurologic injury. Conclusion: Although treatment for severe Covid-19 infections is often aimed at addressing acute respiratory distress syndrome, vasculopathy, and coagulopathy, neurologic injury can also occur. Evidence-based treatments that improve COVID-19 mortality may also increase risk for developing ICH. Providers should be aware of potential neurologic sequelae of COVID-19, diagnostic methods to rule out other causes of ICH, and treatment regimens.

【 授权许可】

Unknown