Total knee arthroplasty in ochronosis

Arthroplasty Today

关键词: Alkaptonuria;    Total knee replacement;    Ochronosis;    Ochronotic arthropathy;    Operative pearls;    Rare conditions;   

DOI  :  10.1016/j.artd.2015.03.003

来源: DOAJ

【 摘 要 】

Alkaptonuria is disorder of tyrosine metabolism due to deficiency of homogentisic oxidase characterized by excretion of homogentisic acid in urine, deposition of oxidized homogensitate pigments in connective tissues and articular cartilages (ochronosis). The result is dark pigmentation and weakening of the tissues resulting in chronic inflammation and osteoarthritis. Management of alkaptonuric ochronic osteoarthritis is usually symptomatic and replacements have comparable outcomes to osteoarthritis in patients without ochronosis. I report a case of a patient with ochronosis of knee treated with total knee replacement and report operative pearls for surgery in this rare disorder.

【 授权许可】

Unknown