Prone positioning monitored by electrical impedance tomography in patients with severe acute respiratory distress syndrome on veno-venous ECMO

Annals of Intensive Care

Ania Nieszkowska¹  Pierre Demondion¹  Charles-Edouard Luyt¹  Guillaume Lebreton¹  Nicolas Bréchot¹  Loïc Le Guennec¹  Guillaume Franchineau¹  Matthieu Schmidt¹  Simon Bourcier¹  Guillaume Hekimian¹  Alain Combes¹ 

[1] INSERM, UMRS_1166-iCAN, Institute of Cardiometabolism and Nutrition, Sorbonne Universités, UPMC Univ Paris 06;

关键词: Acute respiratory distress syndrome;    Prone position;    Electric impedance tomography;    Extracorporeal membrane oxygenation;   

DOI  :  10.1186/s13613-020-0633-5

来源: DOAJ

【 摘 要 】

Abstract Background Prone positioning (PP) during veno-venous ECMO is feasible, but its physiological effects have never been thoroughly evaluated. Our objectives were to describe, through electrical impedance tomography (EIT), the impact of PP on global and regional ventilation, and optimal PEEP level. Methods A monocentric study conducted on ECMO-supported severe ARDS patients, ventilated in pressure-controlled mode, with 14-cmH2O driving pressure and EIT-based “optimal PEEP”. Before, during and after a 16-h PP session, EIT-based distribution and variation of tidal impedance, VTdorsal/VTglobal ratio, end-expiratory lung impedance (EELI) and static compliance were collected. Subgroup analyses were performed in patients who increased their static compliance by ≥ 3 mL/cmH2O after 16 h of PP. Results For all patients (n = 21), tidal volume and EELI were redistributed from ventral to dorsal regions during PP. EIT-based optimal PEEP was significantly lower in PP than in supine position. Median (IQR) optimal PEEP decreased from 14 (12–16) to 10 (8–14) cmH2O. Thirteen (62%) patients increased their static compliance by ≥ 3 mL/cmH2O after PP on ECMO. This subgroup had higher body mass index, more frequent viral pneumonia, shorter ECMO duration, and lower baseline VTdorsal/VTglobal ratio than patients with compliance ≤ 3 mL/cmH2O (P < 0.01). Conclusion Although baseline tidal volume distribution on EIT may predict static compliance improvement after PP on ECMO, our results support physiological benefits of PP in all ECMO patients, by modifying lung mechanics and potentially reducing VILI. Further studies, including a randomized–controlled trial, are now warranted to confirm potential PP benefits during ECMO.

【 授权许可】

Unknown