A “cell-free treatment” for tendon injuries: adipose stem cell-derived exosomes

European Journal of Medical Research

Tianzhu Liu¹  Yixuan Chen²  Li Jiang²  Kexin Lyu²  Jingwei Lu²  Xinyue Liu²  Xueli Liu²  Yujie Li²  Sen Li³ 

[1] Neurology Department, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University;School of Physical Education, Southwest Medical University;Spinal Surgery Department, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University;

关键词: Exosomes;    Adipose-derived stem cells;    Tendon;    Mechanism;    Role;   

DOI  :  10.1186/s40001-022-00707-x

来源: DOAJ

【 摘 要 】

Abstract Tendon injuries are widespread and chronic disorders of the musculoskeletal system, frequently caused by overload of the tendons. Currently, the most common treatment for tendon injuries is "cell-free therapy", of which exosomes, which can treat a host of diseases, including immune disorders, musculoskeletal injuries and cardiovascular diseases, are one kind. Among the many sources of exosomes, adipose-derived stem cell exosomes (ASC-Exos) have better efficacy. This is attributed not only to the ease of isolation of adipose tissue, but also to the high differentiation capacity of ASCs, their greater paracrine function, and immunomodulatory capacity compared to other exosomes. ASC-Exos promote tendon repair by four mechanisms: promoting angiogenesis under hypoxic conditions, reducing the inflammatory response, promoting tendon cell migration and proliferation, and accelerating collagen synthesis, thus accelerating tendon healing. This review focuses on describing studies of preclinical experiments with various exosomes, the characteristics of ASC-Exos and their mechanisms of action in tendon healing, as well as elaborating the limitations of ASC-Exos in clinical applications.

【 授权许可】

Unknown