An Update on Innate Immune Responses during SARS-CoV-2 Infection

Viruses

Shuaiyin Chen¹  Yu Zhang¹  Wangquan Ji¹  Guangcai Duan¹  Yuefei Jin¹  Weiguo Zhang¹ 

[1] Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, China;

关键词: SARS-CoV-2;    innate immune response;    type I interferons;   

DOI  :  10.3390/v13102060

来源: DOAJ

【 摘 要 】

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a member of the Coronaviridae family, which is responsible for the COVID-19 pandemic followed by unprecedented global societal and economic disruptive impact. The innate immune system is the body’s first line of defense against invading pathogens and is induced by a variety of cellular receptors that sense viral components. However, various strategies are exploited by SARS-CoV-2 to disrupt the antiviral innate immune responses. Innate immune dysfunction is characterized by the weak generation of type I interferons (IFNs) and the hypersecretion of pro-inflammatory cytokines, leading to mortality and organ injury in patients with COVID-19. This review summarizes the existing understanding of the mutual effects between SARS-CoV-2 and the type I IFN (IFN-α/β) responses, emphasizing the relationship between host innate immune signaling and viral proteases with an insight on tackling potential therapeutic targets.

【 授权许可】

Unknown