Impact of Vitamin B12 Insufficiency on Sarcopenia in Community-Dwelling Older Korean Adults

International Journal of Environmental Research and Public Health

Chang Won Won¹  Myung Chul Yoo²  Yeocheon Yun²  Jinmann Chon²  Seon A Chae²  Dong Hwan Yun²  Jong Ha Lee²  Hee-Sang Kim²  Yunsoo Soh²  Sung Joon Chung³  Seung Don Yoo³  Seung Ah Lee³  Dong Hwan Kim³ 

[1] Department of Family Medicine, Kyung Hee University Medical Center, Seoul 02447, Korea;Department of Physical Medicine and Rehabilitation Medicine, Kyung Hee University Medical Center, Seoul 02447, Korea;Department of Physical Medicine and Rehabilitation, Kyung Hee University Hospital at Gangdong, Seoul 05278, Korea;

关键词: vitamin B12;    sarcopenia;    aging;    walking speed;    hand grip strength;   

DOI  :  10.3390/ijerph182312433

来源: DOAJ

【 摘 要 】

Vitamin B12 (B12) is involved as a cofactor in the synthesis of myelin. A lack of B12 impairs peripheral nerve production, which can contribute to sarcopenia. In this cross-sectional study, we aimed to investigate the relationship between B12 insufficiency and sarcopenia in community-dwelling older Korean adults. A total of 2325 (1112 men; 1213 women) adults aged 70–84 years were recruited. The tools used for sarcopenia were based on the Asian Working Group for Sarcopenia (AWGS) guidelines. Individuals with low appendicular skeletal muscle mass index (ASMI) (<7.0 kg/m² for men; <5.4 kg/m² for women) and low hand grip strength (HGS) (<28 kg for men; <18 kg for women) were defined as the sarcopenia group. Among this group, those who showed low physical performance (≤9 points on the Short Physical Performance Battery (SPPB)) were defined as the severe sarcopenia group. B12 concentrations were classified into insufficient (<350 pg/mL) and sufficient (≥350 pg/mL). Univariate and multivariate logistic regression analyses were used to evaluate the relationship between sarcopenia and B12 levels. Low ASMI showed a high incidence in the B12-insufficient group. However, HGS, SPPB, and the severity of sarcopenia showed no correlation with B12. Further, insufficient B12 may affect muscle quantity rather than muscle strength or physical performance.

【 授权许可】

Unknown