The Drosophila F-box protein Fbxl7 binds to the protocadherin Fat and regulates Dachs localization and Hippo signaling

eLife

Brett J Pellock¹  Justin A Bosch²  Taryn M Sumabat²  Iswar K Hariharan²  Yassi Hafezi²  Kevin D Gandhi² 

[1] Department of Biology, Providence College, Providence, United States;Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, United States;

关键词: Hippo pathway;    cell proliferation;    planar cell polarity;    cadherin;    vesicle;    ubiquitin;   

DOI  :  10.7554/eLife.03383

来源: DOAJ

【 摘 要 】

The Drosophila protocadherin Fat (Ft) regulates growth, planar cell polarity (PCP) and proximodistal patterning. A key downstream component of Ft signaling is the atypical myosin Dachs (D). Multiple regions of the intracellular domain of Ft have been implicated in regulating growth and PCP but how Ft regulates D is not known. Mutations in Fbxl7, which encodes an F-box protein, result in tissue overgrowth and abnormalities in proximodistal patterning that phenocopy deleting a specific portion of the intracellular domain (ICD) of Ft that regulates both growth and PCP. Fbxl7 binds to this same portion of the Ft ICD, co-localizes with Ft to the proximal edge of cells and regulates the levels and asymmetry of D at the apical membrane. Fbxl7 can also regulate the trafficking of proteins between the apical membrane and intracellular vesicles. Thus Fbxl7 functions in a subset of pathways downstream of Ft and links Ft to D localization.

【 授权许可】

Unknown