Synthesis, characterization, DNA interaction and pharmacological studies of substituted benzophenone derived Schiff base metal(II) complexes

Journal of Saudi Chemical Society

P. Subbaraj¹  J. Dharmaraja²  A. Ramu³  N. Raman⁴ 

[1] Department of Chemistry, Devanga Arts College (Autonomous), Aruppukottai 626 101, Tamil Nadu, India;Department of Chemistry, Sree Sowdambika College of Engineering, Aruppukottai 626 134, Tamil Nadu, India;Department of Inorganic Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai 625 021, Tamil Nadu, India;Research Department of Chemistry, V.H.N.S.N. College(Autonomous), Virudhunagar 626 001, Tamil Nadu, India;

关键词: Benzophenone;    Schiff base;    Metal(II) complexes;    XRD, SEM;    DNA cleavage;   

DOI  :  10.1016/j.jscs.2014.05.002

来源: DOAJ

【 摘 要 】

A new bidentate NO type Schiff base ligand (HL), derived from 2-hydroxy-4-methoxyphenyl)phenylmethanone with aniline and its metal(II) [M = Mn, Co, Ni, Cu and Zn] complexes has been synthesized. The synthesized ligand and the metal(II) complexes were structurally characterized by analytical, spectral (FT-IR, UV–vis., 1H NMR, FAB-Mass, TGA/DTA and EPR) as well as molar conductance and magnetic studies. All the complexes are non-electrolytes having 1:2 stoichiometry. They adopt tetrahedral and octahedral geometry. Thermal behavior of metal(II) complexes (1a–1c) shows loss of coordinated water molecules in the first step followed by the decomposition of ligand moieties in a respective manner and leads to form an air stable metal oxide as the final residue. Micro crystalline nature and the presence of coordinated water molecules have been confirmed by powder XRD, SEM and thermal analyses. The ligand and its complexes have efficient bio-efficacy, DNA binding and cleavage ability.

【 授权许可】

Unknown