Circulating miR-208b and miR-34a Are Associated with Left Ventricular Remodeling after Acute Myocardial Infarction

International Journal of Molecular Sciences

Jing He¹  Mingxia Zhou¹  Xi Wang²  Xuehan Ma³  Xianchun Meng³  Xue Zhao³  Pin Lv³  Weiwei Meng³  Fucheng He³  Shuling Dong³ 

[1] Basic Medical College, Zhengzhou University, Zhengzhou 450052, China;Department of Cardiology, the First Affiliated Hospital, Zhengzhou University,Zhengzhou 450052, China;Department of Medical Laboratory, the First Affiliated Hospital, Zhengzhou University,Zhengzhou 450052, China;

关键词: microRNAs;    myocardial infarction;    left ventricular remodeling;    prognosis;    circulating biomarkers;   

DOI  :  10.3390/ijms15045774

来源: DOAJ

【 摘 要 】

Left ventricular remodeling after acute myocardial infarction (AMI) is associated with adverse prognosis. It is becoming increasingly clear that circulating miRNAs could be promising biomarkers for various pathological processes in the heart, including myocardial infarction, myocardial remodeling and progression to heart failure. In the present study, a total of 359 consecutive patients were recruited. Plasma samples were collected on admission. Echocardiographic studies were performed during the admission and at six months follow-up after AMI. Remodeling was defined as an at least 10% increase from baseline in the left ventricular end-diastolic volume. Plasma miRNA levels were assessed for association with six months mortality or development of heart failure. Results showed that levels of plasma miR-208b and miR-34a were significantly higher in patients with remodeling thanthose without. Increased miRNA levels were strongly associated with increased risk of mortality or heart failure within six months for miR-208b (OR 17.91, 95% confidence interval = 2.07–98.81, p = 0.003), miR-34a (OR 4.18, 95% confidence interval = 1.36–12.83, p = 0.012) and combination of the two miRNAs (OR 18.73, 95% confidenceinterval = 1.96–101.23, p = 0.000). The two miRNA panels reclassified a significant proportion of patients with a net reclassification improvement of 11.7% (p = 0.025) and an integrated discrimination improvement of 7.7% (p = 0.002). These results demonstrated that circulating miR-208b and miR-34a could be useful biomarkers for predicting left ventricular remodeling after AMI, and the miRNA levels are associated with increased risk of mortality or heart failure.

【 授权许可】

Unknown