期刊论文详细信息
Micromachines
Multiscale Modeling of Skeletal Muscle Active Contraction in Relation to Mechanochemical Coupling of Molecular Motors
Shengmao Lin1  Linxia Gu1  He Wang2  Xiaodong Zhang2  Jiangcheng Chen2 
[1] Department of Mechanical and Materials Engineering, University of Nebraska-Lincoln, Lincoln, NE 68588-0656, USA;Key Laboratory of Education Ministry for Modern Design and Rotor-Bearing System,School of Mechanical Engineering, Xi'an Jiaotong University, Xi'an 710049, China;
关键词: muscle contraction;    non-equilibrium statistical mechanics;    molecular motor;    biomechanical model;    Fokker-Planck Equation;   
DOI  :  10.3390/mi6070902
来源: DOAJ
【 摘 要 】

In this work, a mathematical model was developed to relate the mechanochemical characterizations of molecular motors with the macroscopic manifestation of muscle contraction. Non-equilibrium statistical mechanics were used to study the collective behavior of myosin molecular motors in terms of the complex conformation change and multiple chemical states in one working cycle. The stochastic evolution of molecular motor probability density distribution during the contraction of sarcomere was characterized by the Fokker-Planck Equation. Quick muscle contraction was demonstrated by the collective dynamic behavior of myosin motors, the muscle contraction force, and the muscle contraction velocity-force relation. Our results are validated against published experiments, as well as the predictions from the Hill’s model. The quantitative relation between myosin molecular motors and muscle contraction provides a novel way to unravel the mechanism of force generation.

【 授权许可】

Unknown   

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