The Effects of Brown Algae-Derived Monosaccharide L-Fucose on Lipid Metabolism in C57BL/6J Obese Mice

Nutrients

Hideki Ushio¹  Yuri Kominami¹  Tomohiko Nakao¹  Hina Satone¹  Xiao Yuan¹  Kazuyuki Ohara¹  Tomoya Ueno²  Teruki Aizawa²  Miho Ito² 

[1] Department of Aquatic Bioscience, Graduate School of Agricultural and Life Sciences, University of Tokyo, Tokyo 113-8657, Japan;Yaizu Suisankagaku Industry Co., Ltd., 5-8-13 Kogawa-shimmachi, Yaizu, Shizuoka 425-8570, Japan;

关键词: L-fucose;    intra-abdominal fat;    obesity;    adipogenesis;    metabolic diseases;   

DOI  :  10.3390/nu12123798

来源: DOAJ

【 摘 要 】

Obesity is a global public health problem and a risk factor for several metabolic disorders as well as cancer. In this study, we investigated the effects of L-fucose on lipid metabolism through chronic and acute in vivo experiments in mice. In the chronic test, mice were fed a high-calorie diet (HCD) containing 0.0001%, 0.001%, 0.01%, and 0.1% L-fucose for one month. The L-fucose supplementation inhibited body weight and visceral fat mass gain in HCD-fed mice. The results of the acute test showed that L-fucose increased the ratio of serum high molecular weight adiponectin and enhanced glucose and lipid catabolism. Furthermore, L-fucose also decreased the expression of adipogenic genes (peroxisome proliferator-activated receptor γ and cluster of differentiation 36). In conclusion, this study provides a new approach to combat obesity and the related diseases.

【 授权许可】

Unknown