Ligularia fischeri and its constituent 3,4-dicaffeoylquinic acid improve obesity-induced nonalcoholic fatty liver disease by regulating lipid metabolism and activating AMPK

Journal of Functional Foods

Myungsuk Kim¹  Ahmad Randy²  Chu Won Nho² 

[1] Department of Biological Chemistry, Korea University of Science and Technology, Daejeon, Republic of Korea;Natural Products Research Center, Korea Institute of Science and Technology, Gangneung, Republic of Korea;

关键词: Fatty liver disease;    Metabolic disorders;    Ligularia fischeri;    3,4-dicaffeoylquinic acid;    AMP-activated protein kinase;   

DOI  :  

来源: DOAJ

【 摘 要 】

This study revealed the activity of a Ligularia fischeri extract (LFE) and its constituents to protect against obesity-induced NAFLD using in vitro and in vivo models. In HepG2 cells, LFE and its chemical constituent 3,4-dicaffeoylquinic acid inhibited lipid accumulation by altering lipid metabolism towards fatty acid oxidation through activation of the AMP-activated protein kinase (AMPK) pathway. In high-fat diet-induced obese C57BL/6J mice, oral administration of LFE attenuated the progression of obesity and improved signs of insulin resistance. LFE treatment attenuated development of NAFLD by decreasing fat droplet accumulation and the triacylglycerol content. In vivo activity of LFE was displayed through regulation of hepatic lipid metabolism and activation of hepatic AMPK. Furthermore, LFE was protected against NAFLD by lowering the level of lipid peroxidation through activation of the antioxidant defence system via NRF2 activation. These results indicate that LFE is a potent agent to improve NAFLD.

【 授权许可】

Unknown