Intermittent parathyroid hormone improve bone microarchitecture of the mandible and femoral head in ovariectomized rats

BMC Musculoskeletal Disorders

Ming-Tzu Tsai¹  Pei-Yu Hsu²  Jay Wu³  Ying-Ju Chen⁴  Shun-Ping Wang⁵  Yu-Fen Li⁶  Jui-Ting Hsu⁷  Heng-Li Huang⁷  Fu-Chou Cheng⁸ 

[1]Department of Biomedical Engineering, Hungkuang University

[2]Department of Biomedical Imaging and Radiological Science, China Medical University

[3]Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University

[4]Department of Food and Nutrition, Providence University

[5]Department of Orthopaedics, Taichung Veterans General Hospital

[6]Institute of Biostatistics, China Medical University

[7]School of Dentistry, College of Medicine, China Medical University

[8]Stem Cell Medical Research Center, Department of Medical Research, Taichung Veterans General Hospital

关键词: Parathyroid hormone;    Trabecular bone;    Microcomputed tomography (micro-CT);    Mandible;    Femoral head;   

DOI  :  10.1186/s12891-017-1530-4

来源: DOAJ

【 摘 要 】

Abstract Background Intermittent parathyroid hormone (PTH) can be used to treat osteoporosis of the spine and hip. However, whether it can be used to treat osteoporosis of the mandible is unclear. The purpose of this study was to explore the influence of applying intermittent PTH to ovariectomized rats on the trabecular bone microarchitecture of the mandible and femoral head. Methods Eighteen female rats were divided into three groups: the healthy group, ovariectomized (OVX) group, and OVX + PTH group. The OVX group and OVX + PTH group had an OVX at 8 weeks of age. The OVX + PTH group received intermittent PTH therapy for 12 weeks. The mandibles and femurs of all rats were removed at 20 weeks and were then scanned using microcomputed tomography (micro-CT). Results From the micro-CT analysis, the trabecular bone microarchitecture of the mandible and femoral head are offered as follows: (1) The bone volume fraction and trabecular thickness in the OVX group were lower than those in the healthy group. (2) The bone volume fraction and trabecular thickness in the OVX + PTH group approximated those in the healthy group. Conclusion The conclusions of this study regarding the trabecular bone microarchitecture of the mandible and femoral head are offered as follows: (1) The BV/TV and TbTh in the OVX group were lower than those in the healthy group. (2) The BV/TV and TbTh in the OVX + PTH group approximated those in the healthy group, therefore, intermittent PTH displayed high efficacy for treating femoral or mandibular deterioration of bone microstructure resulting from loss of ovarian function. Osteoporosis of the femur or mandible in the rats was ameliorated by intermittent PTH therapy.

【 授权许可】

Unknown