Regulation of Rho GTPases by RhoGDIs in Human Cancers

Cells

Bo-Yeon Kim¹  HeeGu Lee²  KyoungEun Baek²  Jong-Tae Kim²  HeeJun Cho² 

[1] Anticancer Cancer Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju 28116, Korea;Immunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Korea;

关键词: RhoGDI1;    RhoGDI2;    Rho GTPases;    cancer;    migration;    metastasis;   

DOI  :  10.3390/cells8091037

来源: DOAJ

【 摘 要 】

Rho GDP dissociation inhibitors (RhoGDIs) play important roles in various cellular processes, including cell migration, adhesion, and proliferation, by regulating the functions of the Rho GTPase family. Dissociation of Rho GTPases from RhoGDIs is necessary for their spatiotemporal activation and is dynamically regulated by several mechanisms, such as phosphorylation, sumoylation, and protein interaction. The expression of RhoGDIs has changed in many human cancers and become associated with the malignant phenotype, including migration, invasion, metastasis, and resistance to anticancer agents. Here, we review how RhoGDIs control the function of Rho GTPases by regulating their spatiotemporal activity and describe the regulatory mechanisms of the dissociation of Rho GTPases from RhoGDIs. We also discuss the role of RhoGDIs in cancer progression and their potential uses for therapeutic intervention.

【 授权许可】

Unknown