One-Year Demographical and Clinical Indices of Patients with Chronic Disorders of Consciousness

Brain Sciences

Pranil Pradhan¹  Julia Nekrasova¹  Alexey Vorobiev¹  Denis Shunenkov¹  Ilya Borisov¹  MarinaV. Petrova¹  Elena Luginina¹  Maria Smirnova¹  Vera Pasko¹  Mikhail Kanarskii¹  Igor Pryanikov¹ 

[1] Department for the Study of Chronic Disorder of Consciousness, Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, 107031 Moscow, Russia;

关键词: chronic disorder of consciousness;    vegetative state;    survival rate;    recovery of consciousness;    prognosis;   

DOI  :  10.3390/brainsci11050651

来源: DOAJ

【 摘 要 】

This work aims to evaluate the prognostic value of the demographical and clinical data on long-term outcomes (up to 12 months) in patients with severe acquired brain injury with vegetative state/unresponsive wakefulness syndrome (VS/UWS/UWS) or a minimally conscious state (MCS). Patients (n = 211) with VS/UWS/UWS (n = 123) and MCS (n = 88) were admitted to the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology after anoxic brain injury (n = 53), vascular lesions (n = 59), traumatic brain injury (n = 93), and other causes (n = 6). At the beginning of the 12-month study, younger age and a higher score by the Coma Recovery Scale-Revised (CRS-R) predicted a survival. However, no reliable markers of significant positive dynamics of consciousness were found. Based on the etiology, anoxic brain injury has the most unfavorable prognosis. For patients with vascular lesions, the first three months after injury have the most important prognostic value. No correlations were found between survival, increased consciousness, and gender. The demographic and clinical characteristics of patients with chronic DOC can be used to predict long-term mortality in patients with chronic disorders of consciousness. Further research should be devoted to finding reliable predictors of recovery of consciousness.

【 授权许可】

Unknown