Determinants in Tailoring Antidiabetic Therapies: A Personalized Approach

Global Medical Genetics

Syed T. Raza¹  Almas Khan²  Aliya A. Rizvi²  Farzana Mahdi²  Shrikant Verma²  Sushma Verma²  Mohammad Abbas² 

[1] Department of Biochemistry, Era University, Lucknow Medical College and Hospital, Lucknow, Uttar Pradesh, India;Department of Personalized and Molecular Medicine, Era University, Lucknow, Uttar Pradesh, India;

关键词: diabetes;    precision medicine;    pharmacogenomics;    drug response;   

DOI  :  10.1055/s-0041-1741109

来源: DOAJ

【 摘 要 】

Diabetes has become a pandemic as the number of diabetic people continues to rise globally. Being a heterogeneous disease, it has different manifestations and associated complications in different individuals like diabetic nephropathy, neuropathy, retinopathy, and others. With the advent of science and technology, this era desperately requires increasing the pace of embracing precision medicine and tailoring of drug treatment based on the genetic composition of individuals. It has been previously established that response to antidiabetic drugs, like biguanides, sulfonylureas, dipeptidyl peptidase-4 (DPP-4) inhibitors, glucagon-like peptide 1 (GLP-1) agonists, and others, depending on variations in their transporter genes, metabolizing genes, genes involved in their action, etc. Responsiveness of these drugs also relies on epigenetic factors, including histone modifications, miRNAs, and DNA methylation, as well as environmental factors and the lifestyle of an individual. For precision medicine to make its way into clinical procedures and come into execution, all these factors must be reckoned with. This review provides an insight into several factors oscillating around the idea of precision medicine in type-2 diabetes mellitus.

【 授权许可】

Unknown