Removal of Environmental Nanoparticles Increases Protein Synthesis and Energy Production in Healthy Humans

Frontiers in Bioengineering and Biotechnology

Enrique Caso-Peláez¹  Yaiza Potes⁵  Juan Carlos Bermejo-Millo⁵  Eduardo Antuña⁵  Ana Coto-Montes⁵  Enrique Caso-Onzain⁶ 

[1] Biomedical Unit, BiowAir Total Systems SL, Gijón, Spain;Department of Morphology and Cell Biology, Faculty of Medicine, University of Oviedo, Oviedo, Spain;Innovación Unit, BiowAir Total Systems SL, C/Michel Faraday, Gijón, Spain;Instituto de Investigación Sanitaria Del Principado de Asturias (ISPA), Av. Del Hospital Universitario, Oviedo, Spain;Instituto de Neurociencias del Principado de Asturias (INEUROPA), University of Oviedo, Oviedo, Spain;Scientific CEO MyOmics SL, Gijón, Spain;System and Precision Medicine, Hospital Covadonga Gijón, Gijón, Spain;

关键词: nanoparticles;    air pollution;    filtration;    ATP;    protein synthesis p70S6K;    total antioxidant activity;   

DOI  :  10.3389/fbioe.2022.800011

来源: DOAJ

【 摘 要 】

Currently, industrial activity causes the environmental release of nanoparticles that have multiple adverse effects on population health. There is a clear correlation between the increase in particulate air pollution and the increases in mortality and morbidity rates in both adults and children, which demonstrates the toxic effects of these particles. However, the effect of particle removal on healthy individuals is unknown. Thus, in this preliminary study, we showed, for the first time, how the filtering equipment that we used significantly reduced a large amount of nanoparticles in a minimum time and induced a reduction of oxidative damage in healthy individuals of both sexes after 25, 50 and 100 days of exposure. These effects led to increased protein synthesis and enhanced mitochondrial efficiency, thus resulting in a highly significant triggering of ATP synthesis. These results not only provide insight into the chronic effects that environmental nanoparticles have on individuals prior to the development of pathologies but also demonstrate a system capable of reversing nanoparticle toxicity and allowing cellular energy recovery.

【 授权许可】

Unknown