Capecitabine-induced activation of actinic keratosis: A common but underrecognized adverse event

Current Problems in Cancer: Case Reports

Naiara S. Barbosa¹  Samantha Marley²  Shelly Stepenaskie² 

[1] Corresponding author.;Department of Dermatology, University of New Mexico, School of Medicine, Albuquerque, NM, USA;

关键词: Capecitabine;    Actinic keratosis;    5-fluorouracil;    Adverse event;    Chemotherapy;   

DOI  :  

来源: DOAJ

【 摘 要 】

We report a case of a 70-year-old woman undergoing chemotherapy with capecitabine for breast cancer who presented with a diffuse erythematous facial eruption, consistent with actinic keratosis activation. The emergence of subclinical actinic keratosis with capecitabine treatment is most likely due to this medication being a prodrug of 5-fluorouracil, a commonly used topical treatment for actinic keratosis. Since this adverse reaction is usually self-resolving and can be easily treated, chemotherapy cessation is usually not recommended. Awareness and prompt recognition of this potential adverse effect of capecitabine can prevent discontinuation or delay of chemotherapy.

【 授权许可】

Unknown