Utility of SOFA score, management and outcomes of sepsis in Southeast Asia: a multinational multicenter prospective observational study

Journal of Intensive Care

for Southeast Asia Infectious Disease Clinical Research Network¹  Direk Limmathurotsakul²  Chuen-Yen Lau³  Khie Chen Lie⁴  Nguyen Van Vinh Chau⁵  T. Eoin West⁶ 

[1] ;Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford;Collaborative Clinical Research Branch, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health;Department of Internal Medicine, Cipto Mangunkusumo Hospital;Department of Internal Medicine, Hospital for Tropical Diseases;Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington;

关键词: Sepsis;    Asia, Southeastern;    Organ dysfunction scores;    Patient care bundles;   

DOI  :  10.1186/s40560-018-0279-7

来源: DOAJ

【 摘 要 】

Abstract Background Sepsis is a global threat but insufficiently studied in Southeast Asia. The objective was to evaluate management, outcomes, adherence to sepsis bundles, and mortality prediction of maximum Sequential Organ Failure Assessment (SOFA) scores in patients with community-acquired sepsis in Southeast Asia. Methods We prospectively recruited hospitalized adults within 24 h of admission with community-acquired infection at nine public hospitals in Indonesia (n = 3), Thailand (n = 3), and Vietnam (n = 3). In patients with organ dysfunction (total SOFA score ≥ 2), we analyzed sepsis management and outcomes and evaluated mortality prediction of the SOFA scores. Organ failure was defined as the maximum SOFA score ≥ 3 for an individual organ system. Results From December 2013 to December 2015, 454 adult patients presenting with community-acquired sepsis due to diverse etiologies were enrolled. Compliance with sepsis bundles within 24 h of admission was low: broad-spectrum antibiotics in 76% (344/454), ≥ 1500 mL fluid in 50% of patients with hypotension or lactate ≥ 4 mmol/L (115/231), and adrenergic agents in 71% of patients with hypotension (135/191). Three hundred and fifty-five patients (78%) were managed outside of ICUs. Ninety-nine patients (22%) died. Total SOFA score on admission of those who subsequently died was significantly higher than that of those who survived (6.7 vs. 4.6, p < 0.001). The number of organ failures showed a significant correlation with 28-day mortality, which ranged from 7% in patients without any organ failure to 47% in those with failure of at least four organs (p < 0.001). The area under the receiver operating characteristic curve of the total SOFA score for discrimination of mortality was 0.68 (95% CI 0.62–0.74). Conclusions Community-acquired sepsis in Southeast Asia due to a variety of pathogens is usually managed outside the ICU and with poor compliance to sepsis bundles. In this population, calculation of SOFA scores is feasible and SOFA scores are associated with mortality. Trial registration ClinicalTrials.gov, NCT02157259. Registered 5 June 2014, retrospectively registered.

【 授权许可】

Unknown