期刊论文详细信息
Allergology International
Biomarkers for Allergen Immunotherapy in Cedar Pollinosis
Masao Yamaguchi1  Sawako Masuda2  Satoko Usui2  Makito Shinoda3  Akihiko Hashiguchi3  Takao Fujisawa4  Mizuho Nagao4  Koa Hosoki4  Yukiko Hiraguchi4  Reiko Tokuda4 
[1] Department of Allergy and Rheumatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan.;Department of Otorhinolaryngology, Mie National Hospital, Mie, Saitama, Japan;Department of Special Analysis, BML, Inc., Saitama, Japan;Institute for Clinical Research, Saitama, Japan;
关键词: basophils;    CD203c;    cedar pollinosis;    IgG4;    immunotherapy;   
DOI  :  10.2332/allergolint.09-RAI-0097
来源: DOAJ
【 摘 要 】

To initiate, monitor, and complete effective immunotherapy, biomarkers to predict and visualize the immune responses are needed. First, we need to identify the right candidate for immunotherapy. Secondly, the immune responses induced by immunotherapy should be monitored. For the first objective, analysis of polymorphisms of candidate genes may be helpful, but still be in development. Regarding biomarkers for immune responsese, there are numerous reports that evaluate immunotherapy-induced immune changes such as suppression of effector cells, deviation to Th1 cytokine production, and induction of regulatory T cells. No standardized methods, however, have been established. Among them, a functional assay of blocking IgG activity, the IgE-facilitated allergen binding assay, may be useful. We quantitated induced expression of an activation marker, CD203c, on basophils and found that the assay efficiently predicts sensitivity to particular allergen and severity of the allergen-induced symptoms. In patients who received rush immunotherapy for Japanese cedar pollinosis, reduction in CD203c expression after the therapy was observed, suggesting the utility of the test for monitoring immunotherapy.

【 授权许可】

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