Presentation of SARS-CoV-2 in a Pediatric Heart Transplant Recipient with Multiple Underlying Comorbidities

Transplantology

BibhutiB. Das¹ 

[1] Department of Pediatric Cardiology, University of Mississippi Medical Center, Mississippi Children’s Hospital, 2500 North State Street, Jackson, MS 39211, USA;

关键词: SARS-CoV-2;    COVID-19;    myocarditis;    pediatric heart transplantation;   

DOI  :  10.3390/transplantology2010009

来源: DOAJ

【 摘 要 】

A six-year-old heart transplant recipient with additional significant co-morbidities, including severe hypoxic-ischemic injury, gastrostomy, tracheostomy, and mechanical ventilation dependency, encountered SARS-CoV-2 infection. The patient received tacrolimus and mycophenolate to prevent graft rejection, presented initially with SARS-CoV-2 positive and presumed pseudomonas aeruginosa pneumonia. Twenty-three days later, the patient presented with fever recurrence with evidence for systemic inflammation, which resolved rapidly with high-dose methylprednisolone. Interestingly, while IgM to SARS-CoV-2 was present, IgG was not detected even three months after his first positive test for SARS-CoV-2. The author discusses potential immune mechanisms that might have affected the course of multi-system inflammatory syndrome children (MIS-C) in this patient.

【 授权许可】

Unknown