Heiner Syndrome and Milk Hypersensitivity: An Updated Overview on the Current Evidence

Nutrients

Francesca Mori¹  Simona Barni¹  Mattia Giovannini¹  Elio Novembre²  Lucia Caminiti³  Luca Pecoraro⁴  Lucia Liotti⁵  Riccardo Castagnoli⁶  GianLuigi Marseglia⁶  Francesca Saretta⁷  Carla Mastrorilli⁸  Stefania Arasi⁹ 

[1] Allergy Unit, Department of Pediatrics, Meyer Children’s University Hospital, 50139 Florence, Italy;Department of Health Science, University of Florence, 70126 Florence, Italy;Department of Human Pathology in Adult and Development Age “Gaetano Barresi”, Allergy Unit, Department of Pediatrics, AOU Policlinico Gaetano Martino, 98158 Messina, Italy;Department of Medicine, University of Verona, 37129 Verona, Italy;Department of Pediatrics, AOU Ospedali Riuniti Ancona, Presidio Ospedaliero di Alta Specializzazione “G. Salesi”, 60126 Ancona, Italy;Department of Pediatrics, Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, University of Pavia, 27100 Pavia, Italy;Pediatric Department, Latisana-Palmanova Hospital, Azienda Sanitaria Universitaria Friuli Centrale, 33100 Udine, Italy;Pediatric Unit and Emergency, University Hospital Consortium Corporation Polyclinic of Bari, Pediatric Hospital Giovanni XXIII, 70126 Bari, Italy;Translational Research in Pediatric Specialities Area, Division of Allergy, Bambino Gesù Children’s Hospital, IRCCS, Piazza Sant’Onofrio, 4, 00165 Rome, Italy;

关键词: allergy;    anemia;    cow’s milk;    children;    immunology;    non-IgE-mediated food allergy;   

DOI  :  10.3390/nu13051710

来源: DOAJ

【 摘 要 】

Infants affected by Heiner syndrome (HS) display chronic upper or lower respiratory tract infections, including otitis media or pneumonia. Clinically, gastrointestinal signs and symptoms, anemia, recurrent fever and failure to thrive can be also present. Chest X-rays can show patchy infiltrates miming pneumonia. Clinical manifestations usually disappear after a milk-free diet. The pathogenetic mechanism underlying HS remains unexplained, but the formation of immune complexes and the cell-mediated reaction have been proposed. Patients usually outgrow this hypersensitivity within a few years. The aim of this review is to provide an updated overview on the current evidence on HS in children, with a critical approach on the still undefined points of this interesting disease. Finally, we propose the first structured diagnostic approach for HS.

【 授权许可】

Unknown