CURRENT CONCEPTS OF THE ROLE OF ALTERED BLOOD-BRAIN BARRIER RESISTANCE IN THE PATHOGENESIS OF CNS DISORDERS. PART I: STRUCTURE AND FORMATION OF THE BLOOD-BRAIN BARRIER

Эпилепсия и пароксизмальные состояния

D. V. Blinov¹ 

[1] Pirogov Russian National Research Medical University, Moscow;

关键词: blood-brain barrier;    ontogenesis;    transport systems;    epilepsy;    astrocytes;    pericytes;   

DOI  :  

来源: DOAJ

【 摘 要 】

Abstract: A number of pathophysiologic manifestations can be distinguished that are characteristic of both epilepsy and other common vascular, demyelinating and degenerative central neural system (CNS) diseases. This is a consequence of neural system's endogenizing capacity that determines the possibility of its response with non-specific typical pathologic processes to various pathologies and at different levels of structural and functional organization. The current concept of the blood-brain barrier (BBB) structural and functional organization fundamentally differs from those previously suggested: by early 1980s it became recognized that the BBB represents a dynamic morphofunctional entity, formed by brain capillary endothelial cells and periendothelial structures. This reflects the accumulation of knowledge on this subject that received close attention of scientific and academic communities resulting in an increased number of fundamental and applied BBB studies. In order to realize the role of the BBB in CNS functioning in normal and pathologic settings, it is necessary to clearly understand its development during the ontogeny, as well as exogenous and endogenous factors that can lead to BBB damage ('disrupture'). This will help to verify the number of markers that allow adequate evaluation of the BBB and neural tissue condition, and also to chose a strategy for the management of patients with CNS disorders.

【 授权许可】

Unknown