Neuroinflammation in Ischemic Stroke: Focus on MicroRNA-mediated Polarization of Microglia

Frontiers in Molecular Neuroscience

Lu Liu¹  Yunsha Zhang³  Junping Zhang⁴  Shixin Xu⁴  Yichen Cai⁵  Lu Lian⁵  Liji Yang⁵ 

[1] Binhai New Area Hospital of TCM. Tian Jin, Fourth Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China;Medical Experiment Center, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China;School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China;Tianjin Key Laboratory of Translational Research of TCM Prescription and Syndrome, Tianjin, China;Tianjin University of Traditional Chinese Medicine, Tianjin, China;

关键词: microRNAs;    microglia;    neuroinflammation;    ischemic stroke;    polarization;   

DOI  :  10.3389/fnmol.2020.612439

来源: DOAJ

【 摘 要 】

Ischemic stroke is one of the most common causes of death and disability worldwide. Neuroinflammation is a major pathological event involved in the process of ischemic injury and repair. In particular, microglia play a dual role in neuroinflammation. During the acute phase of stroke onset, M2 microglia are the dominant phenotype and exert protective effects on neuronal cells, whereas permanent M1 microglia contribute to prolonged inflammation and are detrimental to brain tissue. Emerging evidence indicates that microRNAs (miRNAs) may have regulatory effects on microglia-associated inflammation. Thus, we briefly reviewed the dynamic response of microglia after a stroke and assessed how specific miRNAs affect the behavior of reactive microglia. We concluded that miRNAs may be useful novel therapeutic targets to improve stroke outcomes and modulate neuroinflammation.

【 授权许可】

Unknown