The Mercapturomic Profile of Health and Non-Communicable Diseases

High-Throughput

M.João Correia¹  SofiaA. Pereira¹  EmiliaC. Monteiro¹  Valdir Semedo¹  NunoR. Coelho¹  Clara Gonçalves-Dias¹  Judit Morello²  AlexandraM. M. Antunes² 

[1] CEDOC, Chronic Diseases Research Centre, NOVA Medical School, Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, 1169-006 Lisboa, Portugal;Centro de Química Estrutural, Instituto Superior Técnico, ULisboa, 1049-001 Lisboa, Portugal;

关键词: mercapturate pathway;    cysteine-S-conjugates;    chronic inflammation;    N-acetyl-transferase 8;    cysteinyl-leukotrienes;    dopamine;    estrogen;    disulfides;    metabolomics;    biomarkers;   

DOI  :  10.3390/ht8020010

来源: DOAJ

【 摘 要 】

The mercapturate pathway is a unique metabolic circuitry that detoxifies electrophiles upon adducts formation with glutathione. Since its discovery over a century ago, most of the knowledge on the mercapturate pathway has been provided from biomonitoring studies on environmental exposure to toxicants. However, the mercapturate pathway-related metabolites that is formed in humans—the mercapturomic profile—in health and disease is yet to be established. In this paper, we put forward the hypothesis that these metabolites are key pathophysiologic factors behind the onset and development of non-communicable chronic inflammatory diseases. This review goes from the evidence in the formation of endogenous metabolites undergoing the mercapturate pathway to the methodologies for their assessment and their association with cancer and respiratory, neurologic and cardiometabolic diseases.

【 授权许可】

Unknown