Sustainable and selective synthesis of benzimidazole scaffolds using deep eutectic solvents

Current Research in Green and Sustainable Chemistry

A.M. Shebitha¹  P.B. Sherly mole¹  K. Sreekumar¹  K. Hiba¹  M. Shaibuna¹  Muhammed Jeneesh Kariyottu Kuniyil² 

[1] Department of Applied Chemistry, Cochin University of Science and Technology, Cochin, India;Department of Chemistry, Pondicherry University, R V Nagar, Kalapet, Puducherry, 605 014, India;

关键词: Deep eutectic solvents;    Recyclable catalyst;    Benzimidazole synthesis;    Substituent effect;   

DOI  :  

来源: DOAJ

【 摘 要 】

In the present article, the catalytic activity of Zr based DESs (DES 1-DES 3) and Ce based DESs (DES 4-DES 7) was compared for the synthesis of benzimidazole derivatives. Among the seven DESs, excellent conversion was observed for DES 1 (formed from ZrOCl2·8H2O and urea at 1:5 ratio). This might be due to the higher acidity and lower viscosity of DES 1 compared to others. The present method was found to be efficient for the synthesis of 2-substituted benzimidazoles with interesting characteristics such as easy preparation of the catalyst, high product yield, simple reaction procedure and the reusability of the catalyst. It is for the first time, a recyclable and selective protocol for the synthesis of benzimidazoles using deep eutectic solvent was reported.

【 授权许可】

Unknown