Inflammatory Markers Associated With Subclinical Coronary Artery Disease: The Multicenter AIDS Cohort Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

Frank Palella¹  Lawrence Kingsley²  Sabina A. Haberlen³  Kerunne Ketlogetswe³  Russell Tracy⁴  Matthew Budoff⁵  Pantea Rezaeian⁵  Hossein Bahrami⁶  Mallory D. Witt⁷  Wendy S. Post⁸  Michael V. McConnell⁸ 

[1] Laboratory Medicine, and Biochemistry, University of Vermont College of Medicine, Colchester, VT;Cardiovascular Institute and Division of Cardiovascular Medicine, Stanford University, Stanford, CA;Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD;;Departments of Pathology &Division of Cardiology, Harbor‐UCLA Medical Center, Torrance, CA;Division of Cardiovascular Medicine, Keck School of Medicine of University of Southern California, Los Angeles, CA;Northwestern University, Evanston, IL;University of Pittsburgh, PA;

关键词: atherosclerosis;    cardiac biomarkers;    cardiac computed tomography;    coronary artery calcium;    coronary artery disease;    coronary computed tomography scan;   

DOI  :  10.1161/JAHA.116.003371

来源: DOAJ

【 摘 要 】

BackgroundDespite evidence for higher risk of coronary artery disease among HIV+ individuals, the underlying mechanisms are not well understood. We investigated associations of inflammatory markers with subclinical coronary artery disease in 923 participants of the Multicenter AIDS Cohort Study (575 HIV+ and 348 HIV− men) who underwent noncontrast computed tomography scans for coronary artery calcification, the majority (n=692) also undergoing coronary computed tomography angiography. Methods and ResultsOutcomes included presence and extent of coronary artery calcification, plus computed tomography angiography analysis of presence, composition, and extent of coronary plaques and severity of coronary stenosis. HIV+ men had significantly higher levels of interleukin‐6 (IL‐6), intercellular adhesion molecule‐1, C‐reactive protein, and soluble‐tumor necrosis factor‐α receptor (sTNFαR) I and II (all P<0.01) and a higher prevalence of noncalcified plaque (63% versus 54%, P=0.02) on computed tomography angiography. Among HIV+ men, for every SD increase in log‐interleukin‐6 and log intercellular adhesion molecule‐1, there was a 30% and 60% increase, respectively, in the prevalence of coronary stenosis ≥50% (all P<0.05). Similarly, sTNFαR I and II in HIV+ participants were associated with an increase in prevalence of coronary stenosis ≥70% (P<0.05). Higher levels of interleukin‐6, sTNFαR I, and sTNFαR II were also associated with greater coronary artery calcification score in HIV+ men (P<0.01). ConclusionsHigher inflammatory marker levels are associated with greater prevalence of coronary stenosis in HIV+ men. Our findings underscore the need for further study to elucidate the relationships of inflammatory pathways with coronary artery disease in HIV+ individuals.

【 授权许可】

Unknown