Characteristics of Dental Resin-Based Composites in Leukemia Saliva: An In Vitro Analysis

Biomedicines

Ciprian Tomuleasa¹  Sergiu Pasca¹  Florin Onisor²  Andra Piciu³  Alexandru Mester⁴  Marioara Moldovan⁵  Stanca Cuc⁵  Miuta Filip⁵ 

[1] Department of Hematology, Institute of Oncology “Ion Chiricuta”, University of Medicine and Pharmacy “Iuliu Hatieganu”, 400012 Cluj-Napoca, Romania;Department of Maxillofacial Surgery and Implantology, University of Medicine and Pharmacy “Iuliu Hatieganu”, 400012 Cluj-Napoca, Romania;Department of Medical Oncology, Institute of Oncology “Ion Chiricuta”, University of Medicine and Pharmacy “Iuliu Hatieganu”, 400012 Cluj-Napoca, Romania;Department of Oral Health, University of Medicine and Pharmacy “Iuliu Hatieganu”, 400012 Cluj-Napoca, Romania;Department of Polymer Composites, Institute of Chemistry “Raluca Ripan”, University Babes-Bolyai, 400294 Cluj-Napoca, Romania;

关键词: leukemia;    oral health;    saliva;    dental composite;    resin-based composite;   

DOI  :  10.3390/biomedicines9111618

来源: DOAJ

【 摘 要 】

Background: The aim was to analyze, in vitro, four resin based composite systems (RBCs) immersed in saliva of leukemia patients before starting chemotherapy regiments. Material and methods: Saliva was collected from 20 patients (4 healthy patients, 16 leukemia patients). Resin disks were made for each RBC and were immersed in the acute leukemia (acute lymphocytic (ALL), acute myeloid (AML)), chronic leukemia (chronic lymphocytic (CLL), chronic myeloid (CML)), Artificial saliva and Control environment, and maintained for seven days. At the end of the experiment, the characteristics and the effective response of saliva from the studied salivas’ on RBCs was assessed using water sorption, water solubility, residual monomer and scanning electron microscopy (SEM). Data analysis was performed and a p-value under 0.05 was considered statistically significant. Results: The behaviour of RBCs in different immersion environments varies according to the characteristics of the RBCs. RBCs with a higher filler ratio have a lower water sorption. The solubility is also deteriorated by the types of organic matrix and filler; the results of solubility being inversely proportional on the scale of negative values compared to sorption values. Chromatograms of residual monomers showed the highest amount of unreacted monomers in ALL and AML, and the Control and artificial saliva environments had the smallest residual monomer peaks. Because of the low number of differences between the experimental conditions, we further considered that there were no important statistical differences between experimental conditions and analysed them as a single group. Conclusion: The influence of saliva on RBCs depends on the type of leukemia; acute leukemia influenced the most RBCs by changing their properties compared to chronic leukemia.

【 授权许可】

Unknown