Investigating the Association Between rs2439302 Polymorphism and Thyroid Cancer: A Systematic Review and Meta-Analysis

Frontiers in Surgery

Xuefeng Liu¹  Jiajie Xu¹  Chuanming Zheng²  Yawen Guo³  Wanchen Zhang⁴  Minghua Ge⁵  Ru He⁷ 

[1] Head and Neck Center, Cancer Center, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, China;;Department of Head and Neck Surgery, Otolaryngology &Department of Public Health, Zhejiang University School of Medicine, Hangzhou, China;Key Laboratory of Endocrine Gland Diseases of Zhejiang Province, Hangzhou, China;Neck and Breast Department 3, Tumour Hospital of Mudanjiang City, Mudanjiang, China;School of Basic Medical Sciences and Forensic Medicine, Hangzhou Medical College, Hangzhou, China;Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, China;

关键词: thyroid cancer;    rs2439302;    meta-analysis;    single nucleotide polymorphism;    genome-wide association studies;   

DOI  :  10.3389/fsurg.2022.877206

来源: DOAJ

【 摘 要 】

Background and AimsThe extent of surgical treatment for most patients with thyroid cancer (TC) remains controversial and varies widely. As an emerging technology, genetic testing facilitates tumor typing and disease progression monitoring and is expected to influence the choice of surgical approach for patients with TC. Recent genome-wide association studies (GWASs) have identified that rs2439302 (8p12) variants near NRG1 are associated with TC risk; however, the results remain inconclusive. Therefore, we aimed to perform a meta-analysis to clarify the association between rs2439302 variants and the risk of TC.MethodsWe search eligible studies using Pubmed, Scopus, Embase, Web of Science, and Cochrane library by July 2021. We analyzed the pooled OR and the corresponding 95% confidence interval (95% CI) of the included studies and then conducted subgroup analysis according to the ethnicity. We also performed a sensitivity analysis to validate the findings.ResultsThis meta-analysis finally included 7 studies involving 6,090 cases and 14,461 controls. Results showed that the G allele of the rs2439302 polymorphism was a significant risk factor of TC in Allele (G/C), Dominant (GG+GC/CC), Recessive (GG/GC+CC), Homozygote (GG/CC), Heterozygote (GC/CC) models, with pooled ORs of 1.38 (95%CI, 1.31–1.45), 1.51 (95%CI, 1.41–1.62), 1.52 (95%CI, 1.40–1.66), 1.90 (95%CI, 1.71–2.10), and 1.40 (95%CI, 1.30–1.51), respectively. The subgroup analysis showed that rs2439302 polymorphism was associated with higher TC risk in different ethnicities with OR > 1. The sensitivity analysis exhibited that the results were stable by omitting any included studies.ConclusionsThe study revealed that rs2439302 variants were associated with higher TC risk and may have a major influence on the choice of operative approach for patients with TC.

【 授权许可】

Unknown