Efficacy of two locally produced oxfendazole formulations for the treatment of cysticercosis in naturally infected pigs

Revista Peruana de Medicina Experimental y Salud Pública

Grupo de Trabajo en Cisticercosis en Perú¹  Javier A. Bustos²  Teresa Lopez²  Héctor H. Garcia²  Gianfranco Arroyo³  Juan F. Calcina⁴  Robert H. Gilman⁵  Ana Vargas-Calla⁵  Armando E. Gonzalez⁵  Luis A. Gomez-Puerta⁵  Linda Gallegos⁵ 

[1] doctor en MedicinaVeterinaria;magíster en Salud Animal;Centro de Salud Global y Departamento de Microbiología, Universidad Peruana Cayetano Heredia, Lima, Perú.Médico veterinario;Centro de Salud Global y Departamento de Microbiología, Universidad Peruana Cayetano Heredia, Lima, Perú.médico cirujano, doctor en Salud Pública;Facultad de Medicina Veterinaria, Universidad Nacional Mayor de San Marcos, Lima, Perú.Médico veterinario;

关键词: cisticercosis;    dosificación;    quistes;    porcinos;    taenia solium;    peru;   

DOI  :  10.17843/rpmesp.2021.382.6539

来源: DOAJ

【 摘 要 】

The efficacy of two locally produced oxfendazole (OFZ) formulations against cysticercosis at 22,5% and 10%, versus a commercial formulation (Synanthic 9,06%) was evaluated in twenty-two naturally infected pigs that received a single oral dose of 30 mg/kg. Pigs were sacrificed at eight weeks post-treatment to evaluate the cysts found in their carcasses, and to determine the cysticidal efficacy, which was defined as the proportion of degenerated cysts over total cysts. Only degenerated cysts were found in muscle, heart, and tongue of pigs treated with OFZ in all groups, which shows an efficacy of 100%. Viable and degenerated cysts were found in brains, being the efficacy lower in all groups (65% [commercial OFZ], 47% [local OFZ 22.5%] and 31% [local OFZ 10%], p = 0.355). Locally produced OFZ formulations were similarly effective to the commercial formulation and may provide a practical alternative for the treatment of porcine cysticercosis.

【 授权许可】

Unknown