Adjuvant Treatments of Adult Melanoma: A Systematic Review and Network Meta-Analysis

Frontiers in Oncology

Fan Yuan¹  Min Xiao²  Mingyi Jing²  Baohua Zhu²  Mingling Chen³  Jie Zhang³  Jing Shi⁴  Xufan Zhang⁵  Yi Cai⁶ 

[1] Andrology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China;Chengdu University of Traditional Chinese Medicine, Chengdu, China;Department of Dermatology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China;Department of Internal Medicine, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China;Department of Nuclear Medicine, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China;Department of Oncology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China;;Department of Urology &

关键词: melanoma;    adjuvant treatment;    network meta-analysis;    nivolumab;    ipilimumab;    trametinib;   

DOI  :  10.3389/fonc.2022.926242

来源: DOAJ

【 摘 要 】

Multiple treatments of unresectable advanced or metastatic melanoma have been licensed in the adjuvant setting, causing tremendous interest in developing neoadjuvant strategies for melanoma. Eligible studies included those that compared overall survival/progression-free survival/grade 3 or 4 adverse events in patients with unresectable advanced or metastatic melanoma. Seven eligible randomized trials with nine publications were included in this study. Direct and network meta-analysis consistently indicated that nivolumab+ipilimumab, nivolumab, and trametinib could significantly improve overall survival and progression-free survival compared to ipilimumab in advanced melanoma patients. Compared to ipilimumab, nivolumab, dacarbazine, and ipilimumab+gp100 had a reduced risk of grade 3/4 adverse reactions. The nivolumab+ipilimumab combination had the highest risk of adverse events, followed by ipilimumab+dacarbazine and trametinib. Combination therapy was more beneficial to improve overall survival and progression-free survival than monotherapy in advanced melanoma treatment, albeit at the cost of increased toxicity. Regarding the overall survival/progression-free survival, ipilimumab+gp100 ranked below ipilimumab+dacarbazine and nivolumab+ipilimumab, although it had a smaller rate of grade 3 or 4 AEs than other treatments (except nivolumab). Nivolumab is the optimum adjuvant treatment for unresectable advanced or metastatic melanoma with a good risk-benefit profile. In order to choose the best therapy, clinicians must consider the efficacy, adverse events, and physical status.

【 授权许可】

Unknown