Acute cerebral infarction in a patient with nodular glomerulopathy—Atypical features and differential diagnosis

Kaohsiung Journal of Medical Sciences

Hung-Chun Chen¹  洪啟智¹  Chi-Chih Hung¹  Shih-Meng Yeh¹  Jia-Jung Lee¹  葉時孟¹  陳鴻鈞¹  李佳蓉¹ 

[1] Division of Nephrology, Department of Internal Medicine, Chung-Ho Memorial Hospital, Kaohsiung, Taiwan;

关键词: Arterial embolism;    Light chain deposition disease;    Nephrotic syndrome;    Nodular glomerulopathy;   

DOI  :  10.1016/j.kjms.2010.04.002

来源: DOAJ

【 摘 要 】

Nodular glomerulopathy is a pattern of glomerular injury observed under light microscopy that could result from several diseases presented as nephrotic syndrome clinically. Compared with venous thrombosis, cerebral infarction resulting from arterial thrombosis is relatively rare in these patients. We report an interesting case of severe nephrotic syndrome complicated with acute cerebral infarction, and renal biopsy revealed nodular glomerulopathy under light microscopy. Immunofluorescent staining was positive for λ light chain (predominant) and κ light chain, mainly in mesangial areas, and electron microscopic study showed massive amorphous acellular deposits also in mesangial areas with some local extension to subendothelial space. Congo red stain gave negative results under polarized light. The case was concluded as an atypical presentation of light chain deposition disease both pathologically and clinically.

【 授权许可】

Unknown