期刊论文详细信息
eLife | |
Modulating protein quality control | |
Ryan J Paxman1  R Luke Wiseman2  Lars Plate2  Jeffery W Kelly3  | |
[1] Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, United States;Department of Chemistry, The Scripps Research Institute, La Jolla, United States;Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, United States; | |
关键词: endoplasmic reticulum; unfolded protein response; small molecule screening; ATF6-alpha; ER stress; site-1-protease; | |
DOI : 10.7554/eLife.18431 | |
来源: DOAJ |
【 摘 要 】
Small molecules that modulate the unfolded protein response have the potential to treat a variety of human protein misfolding diseases.
【 授权许可】
Unknown