Modulating protein quality control

eLife

Ryan J Paxman¹  R Luke Wiseman²  Lars Plate²  Jeffery W Kelly³ 

[1] Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, United States;Department of Chemistry, The Scripps Research Institute, La Jolla, United States;Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, United States;

关键词: endoplasmic reticulum;    unfolded protein response;    small molecule screening;    ATF6-alpha;    ER stress;    site-1-protease;   

DOI  :  10.7554/eLife.18431

来源: DOAJ

【 摘 要 】

Small molecules that modulate the unfolded protein response have the potential to treat a variety of human protein misfolding diseases.

【 授权许可】

Unknown