l-Leucine Supplementation Worsens the Adiposity of Already Obese Rats by Promoting a Hypothalamic Pattern of Gene Expression that Favors Fat Accumulation

Nutrients

Fabio B. Lima¹  Francisco L. Torres-Leal¹  Amanda B. Campaña¹  Thais T. Zampieri¹  Jose Donato Jr.¹ 

[1]Department of Physiology and Biophysics, Institute of Biomedical Sciences,University of São Paulo, São Paulo 05508-000, Brazil

关键词: BCAA;    amino acids;    obesity;    high-fat diet;    energy balance;    food intake;    energy expenditure;    hypothalamus;   

DOI  :  10.3390/nu6041364

来源: DOAJ

【 摘 要 】

Several studies showed that l-leucine supplementation reduces adiposity when provided before the onset of obesity. We studied rats that were exposed to a high-fat diet (HFD) for 10 weeks before they started to receive l-leucine supplementation. Fat mass was increased in l-leucine-supplemented rats consuming the HFD. Accordingly, l-leucine produced a hypothalamic pattern of gene expression that favors fat accumulation.In conclusion, l-leucine supplementation worsened the adiposity of rats previously exposed to HFD possibly by central mechanisms.

【 授权许可】

Unknown