期刊论文详细信息
Nutrients | |
l-Leucine Supplementation Worsens the Adiposity of Already Obese Rats by Promoting a Hypothalamic Pattern of Gene Expression that Favors Fat Accumulation | |
Fabio B. Lima1  Francisco L. Torres-Leal1  Amanda B. Campaña1  Thais T. Zampieri1  Jose Donato Jr.1  | |
[1] Department of Physiology and Biophysics, Institute of Biomedical Sciences,University of São Paulo, São Paulo 05508-000, Brazil; | |
关键词: BCAA; amino acids; obesity; high-fat diet; energy balance; food intake; energy expenditure; hypothalamus; | |
DOI : 10.3390/nu6041364 | |
来源: DOAJ |
【 摘 要 】
Several studies showed that l-leucine supplementation reduces adiposity when provided before the onset of obesity. We studied rats that were exposed to a high-fat diet (HFD) for 10 weeks before they started to receive l-leucine supplementation. Fat mass was increased in l-leucine-supplemented rats consuming the HFD. Accordingly, l-leucine produced a hypothalamic pattern of gene expression that favors fat accumulation.In conclusion, l-leucine supplementation worsened the adiposity of rats previously exposed to HFD possibly by central mechanisms.
【 授权许可】
Unknown